Leaf Pharma

Product Introduction

Rozel Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

Rozel Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses Of Rozel Injection

Osteoporosis

Benefits Of Rozel Injection

In Osteoporosis

Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Rozel Injection slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.

You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Side Effects Of Rozel Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common Side Effects Of Rozel

Musculoskeletal (bone, muscle or joint) pain

Pain in extremities

Nerve pain

Constipation

Rash

Headache

How To Use Rozel Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Rozel Injection Works

Rozel Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

Safety Advice

Alcohol

Caution is advised when consuming alcohol with Rozel Injection.

Pregnancy

Rozel Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

Rozel Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breast milk and harm the baby.

Driving

Rozel Injection does not usually affect your ability to drive.

Kidney

Rozel Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Rozel Injection may be needed.

Liver

Rozel Injection should be used with caution in patients with severe liver disease. Dose adjustment of Rozel Injection may be needed.

Introduction To Esentra 120mg Injection

Esentra 120mg Injection consists of the active ingredient Denosumab. It is a medication used to treat osteoporosis, characterized by weakened bones. It is also prescribed to prevent bone complications in patients with certain types of cancer, such as multiple myeloma and bone metastases. Esentra 120mg Injection works by inhibiting a protein called RANK ligand, which plays a role in the breakdown of bone tissue. Studies proved it can significantly increase bone density, reducing fracture risk in postmenopausal women with osteoporosis and patients with cancer-related bone loss. Close monitoring of renal function may be necessary for patients with moderate renal impairment.

Esentra 120mg Injection should not be used in individuals with known hypersensitivity or allergic reactions to its components. Adequate calcium and vitamin D supplementation is required to ensure during the treatment. It is not approved for use in children and adolescents. Its safety and effectiveness in pediatric populations have not been established, so its use is contraindicated in individuals under 18. This medication should be used cautiously in individuals with pre-existing hypoparathyroidism, characterized by low parathyroid hormone levels.

Uses of Esentra 120mg Injection

Esentra 120mg Injection is used in the treatment of the following condition:
· Osteoporosis
· Bone loss due to hormonal therapy in breast or prostate cancer
· Multiple myeloma (cancer affects plasma cells in the bone marrow)
· Bone metastases (cancer that spreads to bone)

Safety Advices for Esentra 120mg Injection  

Pregnancy

The safety of using Esentra 120mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.  

Breast Feeding

Whether Esentra 120mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.  

Lungs

If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Esentra 120mg Injection.  

Liver

Esentra 120mg Injection is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. It is crucial to communicate any pre-existing liver conditions or changes in liver function to your healthcare provider to ensure this medication's safe and effective use.  

Alcohol

It is generally recommended to avoid or limit alcohol consumption while taking Esentra 120mg Injection. Alcohol can interact with this medication, potentially increasing the risk of side effects.  

Driving

Patients receiving Esentra 120mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely. 

Side Effects of Esentra 120mg Injection

Serious:
· Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
· Atypical femoral fractures
· Hypocalcemia (low blood calcium levels)

Common: 
· Injection site reactions
· Back pain
· Musculoskeletal pain
· Infections
· Abdominal pain
· Headache
· Hypophosphatemia (low blood phosphate levels)

Introduction To Denub 60mg Injection

Denub 60mg Injection consists of the active ingredient Denosumab. It is a medication used to treat osteoporosis, characterized by weakened bones. It is also prescribed to prevent bone complications in patients with certain types of cancer, such as multiple myeloma and bone metastases. Denub 60mg Injection works by inhibiting a protein called RANK ligand, which plays a role in the breakdown of bone tissue. Studies proved it can significantly increase bone density, reducing fracture risk in postmenopausal women with osteoporosis and patients with cancer-related bone loss. Close monitoring of renal function may be necessary for patients with moderate renal impairment.

Denub 60mg Injection should not be used in individuals with known hypersensitivity or allergic reactions to its components. Adequate calcium and vitamin D supplementation is required to ensure during the treatment. It is not approved for use in children and adolescents. Its safety and effectiveness in pediatric populations have not been established, so its use is contraindicated in individuals under 18. This medication should be used cautiously in individuals with pre-existing hypoparathyroidism, characterized by low parathyroid hormone levels.

Uses Of Denub 60mg Injection

Denub 60mg Injection is used in the treatment of the following condition:
· Osteoporosis
· Bone loss due to hormonal therapy in breast or prostate cancer
· Multiple myeloma (cancer affects plasma cells in the bone marrow)
· Bone metastases (cancer that spreads to bone)

Safety Advices For Denub 60mg Injection  

Pregnancy

The safety of using Denub 60mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Breast Feeding

Whether Denub 60mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Lungs

If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Denub 60mg Injection.

Liver

Denub 60mg Injection is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. It is crucial to communicate any pre-existing liver conditions or changes in liver function to your healthcare provider to ensure this medication's safe and effective use.

Alcohol

It is generally recommended to avoid or limit alcohol consumption while taking Denub 60mg Injection. Alcohol can interact with this medication, potentially increasing the risk of side effects.

Driving

Patients receiving Denub 60mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.

Side Effects Of Denub 60mg Injection

Serious:
· Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
· Atypical femoral fractures
· Hypocalcemia (low blood calcium levels)

Common: 
· Injection site reactions
· Back pain
· Musculoskeletal pain
· Infections
·  Abdominal pain
· Headache
· Hypophosphatemia (low blood phosphate levels)

Product Introduction

Forteo Injection is a man-made version of parathyroid hormone used to treat men and postmenopausal women who have severe osteoporosis with a high risk of fractures. It works by stimulating new bone formation, which improves bone density and decreases the risk of spinal fractures.

Forteo Injection should be injected under the skin or given by a healthcare professional. You should use it regularly and at the same time each day to get the maximum benefit from it. Usually, it is recommended to take it for a maximum period of 2 years. However, follow the doctor’s advice and complete the course even if you feel better. It should be stored in the refrigerator at a temperature of  2°C to 8°C.

Before taking this medicine, let your doctor know if you have kidney stones or any other kidney problems, as it can cause an increase in the amount of calcium in blood or urine. Pregnant and breastfeeding mothers should also consult with their doctors before taking this medicine. Your doctor may advise a bone scan to monitor the progress of your treatment.

Uses Of Forteo Injection

Osteoporosis

Side Effects Of Forteo Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common Side Effects Of Forteo
·         Joint pain
·         Injection site reactions (pain, swelling, redness)
·         Nausea
·         Leg cramps

How To Use Forteo Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety Advice

Alcohol

Caution is advised when consuming alcohol with Forteo  Injection. Please consult your doctor.

Pregnancy

Forteo Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breastfeeding

Information regarding the use of Forteo Injection during breastfeeding is not available. Please consult your doctor.

Driving

Forteo Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Forteo Injection should be used with caution in patients with kidney disease. Dose adjustment of Forteo Injection may be needed. Please consult your doctor.
Use of Forteo Injection is not recommended in patients with severe kidney disease.

Liver

There is limited information available on the use of Forteo Injection in patients with liver disease. Please consult your doctor.

Product Introduction

Gemtide Injection (2.4ml Each) is a man-made version of parathyroid hormone used to treat men and postmenopausal women who have severe osteoporosis with a high risk of fractures. It works by stimulating new bone formation, which improves bone density and decreases the risk of spinal fractures.

Gemtide Injection (2.4ml Each) should be injected under the skin or given by a healthcare professional. You should use it regularly and at the same time each day to get the maximum benefit from it. Usually, it is recommended to take it for a maximum period of 2 years. However, follow the doctor’s advice and complete the course even if you feel better. It should be stored in the refrigerator at a temperature of  2°C to 8°C.

Before taking this medicine, let your doctor know if you have kidney stones or any other kidney problems, as it can cause an increase in the amount of calcium in blood or urine. Pregnant and breastfeeding mothers should also consult with their doctors before taking this medicine. Your doctor may advise a bone scan to monitor the progress of your treatment.

Uses Of Gemtide Injection

Osteoporosis

Side Effects Of Gemtide Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Gemtide
·         Joint pain
·         Injection site reactions (pain, swelling, redness)
·         Nausea
·         Leg cramps

How To Use Gemtide Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety Advice

Alcohol

Caution is advised when consuming alcohol with Gemtide Injection (2.4ml Each). Please consult your doctor.

Pregnancy

Gemtide Injection (2.4ml Each) may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Breast Feeding

Information regarding the use of Gemtide Injection (2.4ml Each) during breastfeeding is not available.

Driving

Gemtide Injection (2.4ml Each) may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Gemtide Injection (2.4ml Each) should be used with caution in patients with kidney disease. Dose adjustment of Gemtide Injection (2.4ml Each) may be needed. Use of Gemtide Injection (2.4ml Each) is not recommended in patients with severe kidney disease.

Liver

There is limited information available on the use of Gemtide Injection (2.4ml Each) in patients with liver disease.

Introduction To Terifrac Solo 600mcg Injection

Terifrac Solo 600mcg injection contains the active component as Teriparatide. Terifrac Solo 600mcg injection, a synthetic version of parathyroid hormone (PTH) produced by the parathyroid glands, is employed for treating osteoporosis. Osteoporosis is a condition marked by weakened bones, heightening the likelihood of fractures. Fractures caused by osteoporosis can severely affect an individual's quality of life, causing pain and restricting mobility. Terifrac Solo 600mcg injection functions by promoting the creation of new bone tissue and enhancing bone mineral density. 

Individuals who have a known hypersensitivity or allergic reaction to Terifrac Solo 600mcg injection or any of its components should not use this medication. It is contraindicated in individuals with a history of skeletal malignancies, such as osteosarcoma, or those with bone metastases. 

Uses Of Terifrac Solo 600mcg Injection

Postmenopausal osteoporosis

Glucocorticoid-induced osteoporosis

How To Consume Terifrac Solo 600mcg Injection

Terifrac Solo 600mcg injection is typically administered by a healthcare professional. It is usually given as an injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.

Safety Advices For Terifrac Solo 600mcg Injection  

Pregnancy

The safety of Terifrac Solo 600mcg injection use during pregnancy has not been established. If you are pregnant or planning to become pregnant, discussing the potential risks and benefits with your healthcare professional is essential.  

Breast Feeding

Women should consult a doctor while breastfeeding while taking the Terifrac Solo 600mcg injection.  

Lungs

Suppose you have a pre-existing lung condition or are concerned about the safety of the Terifrac Solo 600mcg injection in your lungs. Consulting with your healthcare provider for personalized advice is recommended in that case.  

Liver

If you have a liver condition or are concerned about the safety of Terifrac Solo 600mcg injection, it is recommended to consult your healthcare provider for personalized advice.  

Alcohol

It is generally advisable to avoid consuming alcohol while taking Terifrac Solo 600mcg injection. Alcohol can impair the body's immune system, making it less effective in fighting infections.  

Driving

People may experience side effects, including dizziness, drowsiness, or fatigue, after using Terifrac Solo 600mcg injection. In that case, avoid driving or operating heavy machinery.

Side Effects of Terifrac Solo 600mcg Injection

Bonspark Pen cause some side effects like all medications, although not everyone will experience them. 

Serious
· Hypercalcemia
· Allergic reactions that affect skin and breathing
· Skin reactions at the injection site include rashes, bruising, swelling, anditching
· Osteosarcoma (type of bone cancer)
· Hypercalcemia (increased level of calcium)
· Orthostatic hypotension

Common:
· Arthralgia
· Nerve Pain
· Nausea
· Sickness
· Headache
· Dizziness
· Increased sweating
· Breathlessness
· Muscle cramps
· Increase in blood cholesterol levels
· Chest pain
· Burning sensation below the breast bone
· Anaemia

Injectable Synovial Fluid For Intra-Articular Use In The Treatment Of Arthritis

What sovisc ? 

So-Visc is an introarticular injection produced by biological fermantation method and including ‘hyalunorik acid’ that is in high-purity and is generally used in the treatment of Osteoartirid. The product that is similar to joint-fluids found naturally in joints serves as lubricants and shock-absorber like joint-fluids. Namely, So-Visc is a biological material replacing with fluids which decrease or disappear in patients’ joints. It is Class-Three material which has CE and ISO certificates and which is suitable for European Standards

Where to use?

Osteoartirid treatments

Following artroscopy

Following menuscal repairs

Following anterior cruciate ligament reconstruction

Following mozaicplasty

Patients with isolated patella-femoral knee and as an adjuvant treatment or to delay operations in patients with osteokondral defects.

How to use?

It is not different from other intraarticular injections types in terms of practice. It could be used either for a knee or for both these days.

As a first step, the area which will be injected should be cleaned by an expert. Injection is checked whether the needle reaches the right area.

In case there is excess fluid in joints, this excess fluid is drawn and checked if it is inflammatory. 

When no dangerous situation is observed, the needle is leaved in the knee and So-Visc is injected into the area.

There is no risk to apply painkiller into joints during pre-period of the injection.Patients are advised to abstain from any activities which could make them tired for two or three days.

According to its type and milligram, So-Visc gives treatment between 3-12 months.

 Effects 

So-Visc improves Sodium-Hyalunorat levels in joints in medium-term. It also helps mechanical functions of cartilage to repair by stimulating the body naturally. The product produces an effect as natural joint-fluid and it makes joint lubricitate as well as contributing the prevention of joint pain. Consequently, it relieves pain and relaxes patient.

It replaces synovial fluid after arthroscopy operations, increases mobility in the joint and helps prevent post-operative complications.

Introduction To Zoldonat 4mg Injection

Zoldonat 4mg Injection contains the active substance Zoledronic Acid. It belongs to the group of substances called bisphosphonates. It is used to reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumor. Tumors can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumor-induced hypercalcemia (TIH). It is also used to prevent bone complications in adult patients with multiple myeloma and bone metastases from solid tumors (spread of cancer from the primary site to the bone), in addition to standard cancer therapy.   

Zoldonat 4mg Injection is also indicated to prevent or treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause. It is also used to treat osteoporosis in men. It is used to treat Paget’s disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Other uses include treating or preventing osteoporosis in men and women taking glucocorticoids (a corticosteroid medication that may cause osteoporosis). 

Uses Of Zoldonat 4mg Injection
·         Treat hypercalcemia of malignancy
·         Multiple myeloma
·         Bone metastases from solid tumors
·         Osteoporosis in postmenopausal women
·         Osteoporosis in men
·         Paget’s disease of bone

Safety Advices For Zoldonat 4mg Injection  

Pregnancy

Zoldonat 4mg Injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.   

Breast Feeding

Breastfeeding is not recommended in patients taking Zoldonat 4mg Injection because the medicine passes into the breast milk in small amounts and may harm your baby.   

Lungs

It is unknown whether Zoldonat 4mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.   

Liver

It is unknown whether Zoldonat 4mg Injection can be used in patients with liver disorders. Inform your physician if you have liver problems before initiating the therapy.    

Alcohol

Caution is advised when consuming alcohol with Zoldonat 4mg Injection.

Driving

It is unsafe to drive or operate heavy machinery after using Zoldonat 4mg Injection as this medicine causes drowsiness and sleepiness. 

Side Effects Of Zoldonat 4mg Injection

 Common
·     Nausea, vomiting
·     Fatigue
·   Anemia
·   Bone pain
·   Constipation, diarrhea
·   dyspnea, and fever
·   Swelling in the legs and feet
·   Decreased weight
·   Abdominal pain
·   Muscle pain
·   Tiredness

Introduction To Bonmax Pth 750mcg Cartridge 3's

Bonmax PTH 750mg Cartridge contains the active component of Teriparatide. Bonmax PTH 750mg Cartridge, a synthetic version of parathyroid hormone (PTH) produced by the parathyroid glands, is employed for treating osteoporosis. Osteoporosis is a condition marked by weakened bones, heightening the likelihood of fractures. Fractures caused by osteoporosis can severely affect an individual's quality of life, causing pain and restricting mobility. Bonmax PTH 750mg Cartridge functions by promoting the creation of new bone tissue and enhancing bone mineral density. This medication has been shown to accelerate bone healing in individuals with fractures. It promotes the formation of callus, the initial bridge of new bone that forms during the healing process, leading to faster and more efficient recovery.

Individuals who have a known hypersensitivity or allergic reaction to Bonmax PTH 750mg Cartridge or any of its components should not use this medication. It is contraindicated in individuals with a history of skeletal malignancies, such as osteosarcoma, or those with bone metastases. If an individual has received prior radiation therapy involving the skeleton, the use of this medication is not advised due to the potential risk of osteosarcoma development.

Uses Of Bonmax Pth 750mcg Cartridge 3's

Postmenopausal osteoporosis

Glucocorticoid-induced osteoporosis

Safety Advices For Bonmax Pth 750mcg Cartridge 3's  

Pregnancy

The safety of Bonmax PTH 750mg Cartridge use during pregnancy has not been established. If you are pregnant or planning to become pregnant, discussing the potential risks and benefits with your healthcare professional is essential.  

Breast Feeding

Women should consult a doctor while breastfeeding while taking the Bonmax PTH 750mg Cartridge.  

Lungs

Suppose you have a pre-existing lung condition or are concerned about the safety of the Bonmax PTH 750mg Cartridge in your lungs. Consulting with your healthcare provider for personalized advice is recommended in that case.  

Liver

If you have a liver condition or are concerned about the safety of Bonmax PTH 750mg Cartridge, it is recommended to consult your healthcare provider for personalized advice.  

Alcohol

It is generally advisable to avoid consuming alcohol while taking Bonmax PTH 750mg Cartridge. Alcohol can impair the body's immune system, making it less effective in fighting infections.

Driving

People may experience side effects, including dizziness, drowsiness, or fatigue, after using Bonmax PTH 750mg Cartridge. In that case, avoid driving or operating heavy machinery.

Side Effects Of Bonmax Pth 750mcg Cartridge 3's

Bonspark Pen cause some side effects like all medications, although not everyone will experience them.

Serious:
· Hypercalcemia
· Allergic reactions that affect skin and breathing
· Skin reactions at the injection site include rashes, bruising, swelling, and itching
· Osteosarcoma (type of bone cancer)
· Hypercalcemia (increased level of calcium)
· Orthostatic hypotension (hypertension when stand after sitting or lying position)

Common:
· Arthralgia
· Nerve Pain
· Nausea
· Sickness
· Headache
· Dizziness
· Increased sweating
· Breathlessness
· Muscle cramps
· Increase in blood cholesterol levels
· Chest pain
· Burning sensation below the breast bone
· Anaemia