Leaf Pharma

The brand-name drug formulation LuciMaci 10mg contains macitentan, a potent dual endothelin receptor antagonist. It is primarily prescribed for the treatment of Pulmonary Arterial Hypertension (PAH), a progressive condition characterized by high blood pressure in the arteries of the lungs. LuciMaci aims to delay disease progression and improve exercise capacity in affected individuals. Manufactured under stringent pharmaceutical standards, LuciMaci 10mg ensures therapeutic efficacy and safety for long-term management of PAH.

What is LuciMaci 10mg (Macitentan)?

LuciMaci 10mg contains Macitentan, which is part of a class of drugs known as endothelin receptor antagonists (ERAs). These medications work by blocking the action of endothelin-1 (ET-1), a potent vasoconstrictor peptide that contributes to the narrowing of blood vessels, especially in the lungs. By inhibiting ET-1, Macitentan helps reduce pulmonary vascular resistance, facilitating better blood flow and reduced stress on the heart.

How It Works / Mechanism of Action

Macitentan works by selectively and competitively antagonizing the endothelin receptors ETA and ETB found in pulmonary vascular smooth muscle cells. ET-1, when bound to these receptors, induces vasoconstriction and stimulates proliferation of smooth muscle cells, leading to worsening of PAH. Macitentan effectively blocks both these receptors, thereby:

• Promoting vasodilation (widening of blood vessels)

• Reducing cell proliferation within vessel walls

• lowering pulmonary vascular resistance and boosting oxygen delivery

• Slowing progression of PAH and improving functional capacity

How to Use / Indications

LuciMaci 10mg (Macitentan) is indicated for the long-term treatment of Pulmonary Arterial Hypertension (PAH) in adults classified as WHO Group 1.

Its use is aimed at:

• Reducing the risk of clinical worsening

• Delaying disease progression

• Improving exercise capacity

• Symptom management for individuals with functional class II or III PAH

How to Take / Dosage

Standard Dose:

Adults: One tablet (10 mg) orally once daily, with or without food.

Administration Guidelines:

• Take at the same time each day for consistent blood levels.

• Do not split or crush the tablet.

• Can be taken with or without meals.

Side Effects

While LuciMaci is generally well tolerated, like all medications, it may cause some side effects:

Common Side Effects:

• Anemia (low red blood cells)

• Nasopharyngitis (cold symptoms)

• Headache

• Flu-like symptoms

• Edema, or fluid retention or swelling, usually in the ankles or feet

Serious Side Effects:

• Liver enzyme elevation

• Decreased sperm count (in men)

• Hypotension (low blood pressure)

• Teratogenic effects (harmful during pregnancy)

• Pulmonary edema in PAH secondary to left heart disease

Storage

• Store at room temperature (15°C to 30°C).

• Keep in original packaging to protect from light and moisture.

• Keep out of reach of children.

• Do not use after the expiry date printed on the packaging.

Benefits

LuciMaci offers several clinical benefits:

• Slows disease progression of PAH

• Improves quality of life and functional class

• Reduces hospitalizations related to PAH complications

• increases tolerance to exercise (as determined by a 6-minute walk).

• Orally administered once daily – improving adherence